AB1009 INVERSE CORRELATION BETWEEN NONHDL CHOLESTEROL AND INFLAMMATORY BOWEL DISEASE IN SPONDYLOARTHRITIS: A NEW LIPID PARADOX

Background In Spondyloarthritis (SpA) a higher prevalence of cardiovascular comorbidities has been observed, such as diabetes mellitus (DM), arterial hypertension (AHT), dyslipidaemia (DLP), obesity and metabolic syndrome [1]. recent years, several studies have established causal relationship between non-HDL cholesterol (non-HDLC) levels diseases. Non-HDLC offers wide vision proatherogenic lipoproteins containing apolipoprotein B (apoB) -VLDL, IDL, LDL, chylomicron remnants Lp(a)- without being interfered by triglyceride concentrations. Thus, non-HDLC become an innovative risk (CVR) biomarker. Therefore, the Multinational Cardiovascular Risk Consortium [2] recently published set recommendations estimating CVR based on levels. We analyzed in cohort patients with SpA possible associations clinic laboratory data, serum Objectives To analyse whether there is disease-dependent variables (C-reactive protein [CRP] levels, erythrocyte sedimentation rate [ESR], presence HLA-B27, axial or peripheral involvement, structural damage, extra-articular manifestations) Methods Observational, cross-sectional, single-centre study, which included sample 104 both radiographic non-radiographic SpA, whom each variable was individually for its association Classical factors were also analyzed. Results Of most them women (54,8%), mean age 43 33,7% smoked, HLA-B27 positive 52,9% patients, CRP 9,83 mg/L ESR 17,92 mm/h. Axial involvement prevailed over (92,3% vs 26%). Extra-articular manifestations distributed follows: 13,5% uveitis, 7,7% inflammatory bowel disease (IBD) 4,8% psoriasis. 43,3% had damage. None these suffered from prior to diagnosis. Regarding classic factors: AHT observed 16,3%, DM 1.92%, (BMI >30) 14.4%. Mean 144.19 mg/dL (± 36,1), giving this population 12,87% probability suffering at 75. For estimation, we categorized according low (100 - <145 mg/dL), moderate (145 <185 high (185 <220) very (≥220 mg/dL) Lower concentrations found those IBD (117,6 ± 35,7 compared intestinal (146 35,5 (p<0,05). No statistically significant relationships rest variables. Conclusion our elevated (144 13% clinical features analyzed, lower concentration IBD. This could be explained lipid malabsorption, damage epithelium decreases synthesis apo-B48, necessary formation hepatic apo-B100 [3]. may turn into non-HDLC. should kept mind when defining estimator CVR. References [1]Castaneda S, Nurmohamed MT, Gonzlez-Gay MA. rheumatic disease. Best Pract Res Clin Rheumatol. 2016;30: 851-69. [2]Brunner FJ, et al. Application population-based stratification: results Consortium. Lancet. 2019;394(10215):2173–83. [3]Edge SB, Hoeg JM, Schneider PD, Brewer HB Jr. Apolipoprotein humans: liver synthesizes only B-100. Metabolism. 1985;34(8):726–30. Acknowledgements: NIL. Disclosure Interests Declared.